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Synergy has also been shown between ampicillin and aminoglycosides against a range of organisms, including enterococci. Like benzylpenicillin, ampicillin is inactivated by beta lactamases, although other mechanisms may be responsible for resistance in some species. There are geographical variations in the incidence of resistance, Principen Prescription Canada, but most staphylococci and many strains of E. Pharmacokinetics Ampicillin is relatively resistant to inactivation by gastric acid and is moderately well absorbed from the gastrointestinal tract after oral doses. Food can interfere with the absorption of ampicillin so doses should preferably be taken at least 30 minutes before meals.
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