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This fetotoxicity has been similarly noted with other sulfonylureas, such as tolbutamide and tolazamide. In Glucotrol pills Price in rats and rabbits, no teratogenic effects were found. There are no adequate and Glucotrol pill Price controlled studies in pregnant Glucotrol pills Price. Because recent information suggests that abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities, many experts recommend that insulin be used during pregnancy to maintain blood glucose levels as close to normal as possible. This has been reported more frequently with the use of agents with prolonged half-lives.

Pediatric Use Safety and Glucotrol pill Price in children have not been established. Geriatric Use A determination has not been made whether controlled clinical studies of GLUCOTROL included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.

Close monitoring should continue until the physician is assured that the patient is out of danger.

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Severe hypoglycemic reactions with coma, Glucotrol pill Price, or other neurological impairment occur infrequently, but constitute medical Glucotrol pills Price requiring immediate hospitalization. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Type 1 diabetes mellitus, diabetic ketoacidosis, with or without coma. This condition should be treated with insulin.

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In humans, GLUCOTROL appears to lower the blood glucose acutely by stimulating the release of Glucotrol pill Price from the pancreas, an effect dependent upon functioning beta cells in Acheter Mestinon 60 mg France pancreatic islets. The insulinotropic Glucotrol pill Price to a meal occurs within 30 minutes after an oral dose of GLUCOTROL in diabetic Glucotrol pills Price, but Glucotrol pill Price insulin levels do not persist beyond the time of the meal challenge. Blood sugar control persists in some patients for up to 24 hours after a single dose of GLUCOTROL, even though plasma levels have declined to a small fraction of peak levels by that time see Pharmacokinetics below. Peak plasma concentrations occur 1—3 hours after a single oral dose. The half-life of elimination ranges from 2—4 hours in normal subjects, whether given intravenously or orally.

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Total absorption and disposition of an oral dose was unaffected by food in normal volunteers, but absorption was delayed by about 40 minutes, Glucotrol Pills Price. The primary Glucotrol pills Price are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members.

Primary and secondary failure should also be explained.

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Physician Counseling Information Patients In initiating Glucotrol pill Price for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia.

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